Systematic review with meta-analysis: do interferon lambda 3 polymorphisms predict the outcome of interferon-therapy in hepatitis B infection?
نویسندگان
چکیده
منابع مشابه
the role of interferon lambda 3 genetic polymorphisms in response to interferon therapy in chronic hepatitis b patients: an updated meta-analysis
conclusions this study supports the idea that the ifnl3 gene is an important predictor of the response of chb patients to ifn therapy. results nine studies of 1602 chb patients receiving ifn treatment were included. under the random-effects model, patients expressing the variant rs12980275 showed a significantly increased response to ifn therapy (or = 2.85; 95% ci = 1.14 - 4.60). in the subgrou...
متن کاملthe correlation between interferon lambda 3 gene polymorphisms and susceptibility to hepatitis b virus infection
conclusions our study showed no correlation between rs12979860 and rs8099917 snps and chronic hbv infection. further studies, with larger sample sizes and different ethnicities, are necessary to validate our findings. objectives this study was carried-out to investigate the association of ifnl3 gene polymorphisms (rs12979860 and rs8099917) with hbv susceptibility, in chronic hbv-infected patien...
متن کاملThe Correlation Between Interferon Lambda 3 Gene Polymorphisms and Susceptibility to Hepatitis B Virus Infection.
BACKGROUND Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of chronic hepatitis B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection. OBJECTIVES This study was carried-out to investigate the association of IFNL3 gene polymorphisms (rs1...
متن کاملThe Role of Interferon Lambda 3 Genetic Polymorphisms in Response to Interferon Therapy in Chronic Hepatitis B Patients: An Updated Meta-Analysis
CONTEXT Polymorphisms of the interferon lambda 3 (IFNL3) gene have been proposed to be associated with drug-induced clearance of the hepatitis C virus (HCV). However, the role of IFNL3 polymorphisms in the prediction of treatment on chronic hepatitis B (CHB) patients have yielded controversial results. The aim of this study was to clarify the role of IFNL3 polymorphisms (rs12979860, rs8099917, ...
متن کاملstandard and pegylated interferon therapy of hdv infection: a systematic review and meta-analysis
normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: hepatitis d virus (hdv) infection is characterized by rapidly progressive liver disease with adverse prognosis in most patients. although interferon is the only approved anti-hdv therapy, evidence regarding the efficacy and safety of its various regimens is either old or scattered. materials and methods: we sea...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2014
ISSN: 0269-2813
DOI: 10.1111/apt.12631